The contractor will help build a new Asda store for Citygrove in South Ruislip.
Other features include a petrol station, an 11-screen cinema complex and five restaurant facilities.
The works being carried out by Simons will take 60 weeks.
The entire development is split into two sections; retail and residential.
Bellway Homes will carry out the residential side of the scheme, while Simons will deliver the retail/leisure works.
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In addition, the project has extensive 278 Highway Alterations, along with reconfiguration of a neighbouring property's retail park car park, with minor works to other neighbouring commercial accesses.
Tom Robinson, Chief Executive of Simons, said: "We are delighted to be working with Citygrove on this great scheme for Ruislip. Our team are experts complex retail and leisure schemes of this nature and I know we will deliver the project safely and swiftly, with minimal disruption to the local community.
Daemon Sheehan, Construction Director of Citygrove, added: "The scheme has many constraints and challenges and Simons have shown an excellent understanding and planning of the works. The scheme includes many sustainable elements and will achieve a BRREEAM Very Good rating."
Works are due to commence within the next few weeks.
(LM/MH)
