The work is expected to start in the New Year.
The Cornwall Council-led proposals aim to revitalise what is currently a partially derelict area.
Outline planning permission was given for the £170 million project by the Council's Strategic Planning Committee in October and now early demolition work is to take place as the project to create a new neighbourhood with 320 homes, restaurants and cafes, acres of parks and greenspace and other amenities gets under way.
From early February, local contractor DSM will start to pull down Carrick House and St Clement's House, 57 Pydar Street, the Viaduct car park and the Oak Way units.
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Truro Bowl will remain open throughout the works.
Pydar Street, Viaduct and Carrick House car parks will be closed from 01 February. Drivers heading to Truro are urged to make use of the Park and Ride sites. Alternative long-stay parking can be found at Moorfield, Edward Street and Moresk, and short-stay parking at Old Bridge Street.
Signs on the approaches to Truro also show drivers which car parks have spaces available.
Stephen Rushworth, the Council’s Portfolio Holder for the Economy, said: "The demolition works have been planned to begin after the busy Christmas and New Year period to minimise disruption to roads, pavements and local businesses and residents while ensuring access to parking during the most popular time of the year.
"All car parks will remain open for Christmas shoppers. They will not be closed until early February."
A meet-and-greet session with the site manager and contractor will be scheduled for early in the New Year so that people can ask questions and learn more about activity on the site.
Some limited works will be carried out from December, including archaeological investigations, where the contractors will be careful to examine the area and preserve any historical items.
The Carrick Cabins emergency accommodation site, which was put in place by the Council during its response to the pandemic, has now closed and is being decommissioned. The Council has recently opened a new site at New County Hall, which was this week joined by a similar scheme in Camborne.
