Work is underway to repair the viaduct which carries the road over the River Weaver and Weaver Navigation between junction 12 and junction 14 of the motorway.
Features include carriageway resurfacing, replacing a dozen manhole covers and 24 bridge joints.
The eight-week scheme involves a series of closures in late September and early October. The closure dates will be published nearer to their time.
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Highways England has advised anyone heading to Liverpool or Manchester airports to plan ahead for the journey.
Project Manager Mark Mosley said: "These are essential, if routine, wear and tear repairs and will add time to people's journeys.
"It's vital that people plan their journeys carefully over the next few weeks – especially if they are heading to the region's two main airports during a handful of overnight carriageway closures.
"We run a very busy schedule of repair, maintenance and upgrading work across the whole network, and unfortunately it isn't possible to organise everything we do to avoid the holiday season."
(LM/CD)
