The firm's specialist science and health team will join Arcadis to complete the world-leading centre.
As well as being a new home for the UCL Queen Square Institute of Neurology, the development will also serve as a hub for the UK Dementia Research Institute.
The centre will be built on Gray's Inn Road at the site of the Eastman Dental Hospital, the former home of UCL's dentistry school which ISG is relocating in a separate £8.5m scheme.
Architectural firm Hawkins/Brown will lead the design team of the neurology hub alongside engineering consultancies, Hoare Lea and Ramboll.
ISG will also manage the pre-construction works package that will cost approximately £110 million over the next four years.
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Kevin Argent, deputy director of UCL Estates & director of Estates Development, said: "We are pleased to have appointed ISG to work with us to deliver a very special building that sits within our Estates Transformation programme, creating a new research and clinical environment for neurological diseases, where patients, clinicians and academics can come together in a state of the art, collaborative, combined facility for the first time."
Lee Hutchinson, managing director for ISG's Science and Health business, added: "We are delighted to have been chosen as the main contractor to design and build UCL's new world-class facility for neurological research, allowing us to showcase our specialist expertise in this sector.
"At ISG we thrive on fostering innovation and collaboration, and we encourage our people to think differently and deliver smarter environments.
"We're proud to be working with UCL again to deliver a science and healthcare facility of exceptional quality.
"A vital space will be created for scientists, researchers and clinicians of this world-renowned institute, to discover new ways to diagnose, treat and ultimately prevent one of the greatest health challenges of our time."
Works are due to begin in early 2020, with completion scheduled for late 2023.
The scheme is part of a decade-long initiative called 'Transforming UCL', which will see the university spend £1.25 billion upgrading its estate to support continuing growth.
(CM/MH)
